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Lactylation, a post-translational modification (PTM) identified in 2019, introduces a novel mechanism by which lactate can modulate protein function and gene expression [3]

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in contrast, reperfusion after hypovolemic shock is dominated by hypoxia-driven pathways with a less pronounced cytokine storm, while surgical reperfusion (e.g., during liver transplantation) is typically controlled, whereas heat stroke-related reperfusion occurs abruptly during cooling, exacerbating mitochondrial dysfunction

Albakri U, Drotos E, Meertens R